Effects of Intra-articular Hypertonic Dextrose and Hyaluronic Acid on Primary Knee Osteoarthritis.

Bangladesh Medical University

Status and phase

Active, not recruiting

Phase 3

Conditions

Mild to Moderate Knee OA

Treatments

Drug: prolotherapy solution of 20% dextrose

Drug: Hyaluronic Acid (HA)

Study type

Interventional

Funder types

Other

Identifiers

NCT07102225

5506

Details and patient eligibility

About

The aim of this study is to compare the effectiveness of intra-articular hypertonic dextrose and hyaluronic acid in managing pain and improving function in patients with primary knee osteoarthritis (KOA). This study will guide us to treat primary KOA patients with dextrose prolotherapy instead of hyaluronic acid more effectively.

Enrollment

56 estimated patients

Sex

All

Ages

40 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Knee OA diagnosis satisfying the American College of Rheumatology clinical and radiographic criteria, Kellgren-Lawrence grade of II and III determined by Postero-anterior knee radiograph.
Participants will have the ability to undergo 3 months of follow-up
Participants who will agree to avoid non-steroidal anti-inflammatory drugs during the research (acetaminophen will be prescribed for intractable pain)

Exclusion criteria

Participants who will give a self-reported history of knee surgery, fracture, or infection.
Kellgren-Lawrence grade IV KOA.
Participants on anticoagulants.
Participants who will have previous history of intra-articular knee injection of HA or prolotherapy within 6 months.
Participants who have malignant disease or secondary KOA.
Participants who will have a history of comorbid illness(es) like chronic heart failure, advanced COPD, end-stage renal failure, advanced liver disease and poorly controlled DM.