Effects of Intra-articular Stromal Vascular Fraction Injection on Clinical Symptoms and Cartilage Health in Osteoarthritic Knees

Shu-Hao Chang, MD

Status

Completed

Conditions

Osteoarthritis, Knee

Treatments

Procedure: Intra-articular Stromal Vascular Fraction Injection

Study type

Interventional

Funder types

Other

Identifiers

NCT06562101

FJUH109069

Details and patient eligibility

About

Background: Osteoarthritis (OA) is a prevalent form of arthritis worldwide. Intra-articular stromal vascular fraction (SVF) injections are a potential therapeutic option for patients with OA. This study aims to assess the effects of intra-articular SVF injections on knee OA. Methods: Ten patients with knee OA participated in this study. After being administered intra-articular SVF injections, their outcomes were evaluated using various questionnaires. MRI T2 mapping was conducted and compared before the intervention and 6 months after. All data underwent analysis using various tests.

Enrollment

10 patients

Sex

All

Ages

35+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged ≥ 35 years.
Patients with degenerative knee OA confirmed via X-ray and classified according to the Kellgren Lawrence Grading Scale 2~4.
Persistent knee pain after nonsurgical treatment.

Exclusion criteria

Arthritis caused by other systemic or local immune diseases.
Patients who have undergone total knee replacement surgery.
Patients who have been administered platelet-rich plasma or hyaluronic acid injections within the past three months.
Patients with symptoms related to degenerative arthritis in the ankle, which affected the assessment of pain.
Patients with severe heart problems and coagulation disorders.
Patients who have taken glucosamine within the previous month.
MRI exclusion conditions, including patients with a heart rhythm regulator who have received vascular surgery with a hemostatic clip and artificial heart valves.