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Effects of Intra-articular Stromal Vascular Fraction Injection on Clinical Symptoms and Cartilage Health in Osteoarthritic Knees

S

Shu-Hao Chang, MD

Status

Completed

Conditions

Osteoarthritis, Knee

Treatments

Procedure: Intra-articular Stromal Vascular Fraction Injection

Study type

Interventional

Funder types

Other

Identifiers

NCT06562101
FJUH109069

Details and patient eligibility

About

Background: Osteoarthritis (OA) is a prevalent form of arthritis worldwide. Intra-articular stromal vascular fraction (SVF) injections are a potential therapeutic option for patients with OA. This study aims to assess the effects of intra-articular SVF injections on knee OA. Methods: Ten patients with knee OA participated in this study. After being administered intra-articular SVF injections, their outcomes were evaluated using various questionnaires. MRI T2 mapping was conducted and compared before the intervention and 6 months after. All data underwent analysis using various tests.

Enrollment

10 patients

Sex

All

Ages

35+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Aged ≥ 35 years.
  • Patients with degenerative knee OA confirmed via X-ray and classified according to the Kellgren Lawrence Grading Scale 2~4.
  • Persistent knee pain after nonsurgical treatment.

Exclusion criteria

  • Arthritis caused by other systemic or local immune diseases.
  • Patients who have undergone total knee replacement surgery.
  • Patients who have been administered platelet-rich plasma or hyaluronic acid injections within the past three months.
  • Patients with symptoms related to degenerative arthritis in the ankle, which affected the assessment of pain.
  • Patients with severe heart problems and coagulation disorders.
  • Patients who have taken glucosamine within the previous month.
  • MRI exclusion conditions, including patients with a heart rhythm regulator who have received vascular surgery with a hemostatic clip and artificial heart valves.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

Stromal Vascular Fraction (SVF)
Experimental group
Description:
Ten patients with knee OA were administered intra-articular SVF injections.
Treatment:
Procedure: Intra-articular Stromal Vascular Fraction Injection

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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