Effects of Intracoronary Prourokinase on the Coronary Flow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction (ERUPTION)

Fudan University

Status and phase: Completed; Phase 4

Conditions: Percutaneous Coronary Intervention; Myocardial Infarction; Thrombolytic Therapy

Treatments: Drug: Tirofiban; Drug: normal saline; Drug: Prourokinase

Study type: Interventional

Funder types: Other

Identifiers

NCT02131220

Zhongshan 2012-134

Details and patient eligibility

About

The purpose of this study is to determine whether intracoronary selective thrombolysis are more effective than tirofiban on the coronary flow during primary percutaneous coronary intervention for the acute myocardial infarction.

Enrollment: 362 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ST-segment elevation AMI within 12 hours of symptom onset

Exclusion criteria

• Contraindications to thrombolysis or PCI
• Patients administered a fibrinolytic agent before PCI
• Patients enrolled in clinical trials

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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362 participants in 3 patient groups, including a placebo group

Prourokinase

Experimental group

Description:

Intracoronary bolus infusion of 20mg prourokinase using selective catheter

Treatment:

Drug: Prourokinase

Tirofiban

Active Comparator group

Description:

Intracoronary tirofiban bolus infusion using selective catheter (10ug/kg)

Treatment:

Drug: Tirofiban

Normal saline

Placebo Comparator group

Description:

Intracoronary saline bolus infusion using selective catheter (20ml)

Treatment:

Drug: normal saline