Effects of Intranasal Oxytocin and Vasopressin on Social Behavior

Hadassah Medical Center

Status: Unknown

Conditions: Healthy

Treatments: Drug: Arginine Vasopressin; Drug: placebo; Drug: Oxytocin

Study type: Interventional

Funder types: Other

Identifiers

NCT01296269

OXTandAVP-HMO-CTIL

Details and patient eligibility

About

The purpose of this study is to investigate the role of a one-time intranasal administration of the oxytocin, vasopressin, or placebo on prosocial decision making such as cooperation and altruism in a healthy population of student controls.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy controls

Exclusion criteria

• Past or present psychiatric, neurological, endocrinological or severe chronic medical illness.
• Use of medications or drugs that would interfere with study results. This includes steroids, medications for psychiatric symptoms like anxiety or depression, stimulants, and medications for high blood pressure. Participants will be asked to tell the investigators of any medications or drugs that they are taking. The investigators will consider the drug interactions with oxytocin and vasopressin prior to study, and participants will not be able to participate in the study if the drug interactions could be dangerous.
• history of drug or alcohol addiction
• Pregnancy or Nursing Status: Because of the risk to an unborn fetus or infant, women who are pregnant or nursing are excluded from this protocol. All females will have a pregnancy test performed no more than 24 hours before each drug administration and will not be able to participate if the pregnancy test is positive.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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150 participants in 3 patient groups, including a placebo group

Vasopressin

Experimental group

Description:

vasopressin condition

Treatment:

Drug: Arginine Vasopressin

oxytocin

Experimental group

Description:

oxytocin condition (syntocinon)

Treatment:

Drug: Oxytocin

placebo

Placebo Comparator group

Treatment:

Drug: placebo