Effects of Intranasal Oxytocin on Emotion Regulation

U

University of Electronic Science and Technology of China

Status and phase

Unknown
Early Phase 1

Conditions

Healthy

Treatments

Drug: Oxytocin
Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT03055546
UESTC-neuSCAN-11

Details and patient eligibility

About

The aim is to examine whether intranasal oxytocin will influence the individuals' emotion regulation ability and related neural mechanisms.

Full description

In the present study, the investigators plan to conduct a between-subject, double-blind, placebo-controlled experiment to investigate the effects of oxytocin on neural, physiological and behavior activity related to emotion regulation. The emotion regulation ability will be assessed by emotional go-nogo task and cognitive reappraisal task. The neural activity will be explored by functional magnetic resonance imaging (fMRI). And the investigators will record participants' heart rate during fMRI to investigate the effects of oxytocin on heart rate variability in emotion regulation process. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration, including Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS), Autism Spectrum Quotient (ASQ), Empathy Quotient (EQ), Interpersonal Reactivity Index (IRI), Action Control Scale (ACS), Emotion Regulation Questionnaire (ERQ), Berkley Expressivity Questionnaire (BEQ), and so on.

Enrollment

80 estimated patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

  • history of head injury;
  • claustrophobia;
  • medical or psychiatric illness.

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

80 participants in 2 patient groups, including a placebo group

Oxytocin
Experimental group
Description:
intranasal administration of oxytocin
Treatment:
Drug: Oxytocin
Placebo
Placebo Comparator group
Description:
intranasal administration of placebo
Treatment:
Drug: Placebo

Trial contacts and locations

0

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Central trial contact

Weihua Zhao, Master

Data sourced from clinicaltrials.gov

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