Effects of Intranasal Oxytocin on Striatal Functional Connectivity

University of Electronic Science and Technology of China

Status: Completed

Conditions: Healthy

Treatments: Drug: Placebos; Drug: Oxytocin

Study type: Interventional

Funder types: Other

Identifiers

NCT03128203

UESTC-neuSCAN-36

Details and patient eligibility

About

To investigate whether 40 IU of intranasal oxytocin treatment can influence the resting-state functional connectivity in healthy males.

Full description

In a double-blind, between-subject, placebo controlled design, investigators plan to investigate the effects of oxytocin treatment on resting-state functional connectivity.

Subject will receive either intranasal oxytocin or placebo administration and go through a seven-minute resting-state scan in MRI scanner to test whether oxytocin changes functional connectivity in the brain. Trait anxiety and mood questionnaires will be administered as control variables.

Enrollment: 135 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

• with MRI Contraindications

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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135 participants in 2 patient groups, including a placebo group

Oxytocin

Experimental group

Treatment:

Drug: Oxytocin

Placebo

Placebo Comparator group

Treatment:

Drug: Placebos