Effects of Intravenous Anesthesia on Postoperative Cognitive Function in Patients Accepted Painless Gastroenteroscopy

Zhejiang University

Status: Unknown

Conditions: Postoperative Cognitive Function

Treatments: Behavioral: a series of tests

Study type: Observational

Funder types: Other

Identifiers

NCT03909633

IR2018001085

Details and patient eligibility

About

The investigators want to study the effect of intravenous anesthesia on postoperative cognitive function in patients accepted gastroenteroscopy ,no additional medication or operation is involved

Full description

The investigators want to study the effect of intravenous anesthesia on postoperative cognitive function in patients accepted gastroenteroscopy ,no additional medication or operation is involved.The investigators assess cognitive function through a series of tests for 4 times( within 3 days before the endoscopy ,2 hours after the endoscopy finished,1 week after the endoscopy,3 months after the endoscopy),including WCST、DSST、DST、HADS、MoCA,through self - contrast,the investigators will conclude whether intravenous anesthesia has bad impact on cognitive function or not .

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• voluntary to participate in
• Vital signs are stable
• no drug or alcohol abuse
• no mental illness
• no severe central system diseases such as brain infarction
• between 18 and 80
• no liver or kidney dysfunction
• will perform endoscopy for various reasons

Exclusion criteria

• illiteracy
• color blindness
• can't write or refused to sign informed consent
• unable to follow up regularly or cooperate with the examination
• drug or alcohol abuse
• hearing or visual serious impairment
• has severe central nervous system diseases such as shoke ,neurosyphilis
• uncontrolled high blood pressure or hyperglycemia
• neurosyphilis
• history of craniotomy for various reasons
• liver and kidney dysfunction
• non-digestive tumors
• history of intravenous or general anesthesia for other causes in the last 3 months

Trial design

1,000 participants in 2 patient groups

A: anesthesia group

Description:

Patients accepting endoscopy check under anesthesia will be included in this group as group A,will doing a series of tests

Treatment:

Behavioral: a series of tests

B:Non-anesthesia group

Description:

patients undergoing endoscopy check without anesthesia will be included in this group as controls voluntarily,namely group B,will doing a series of tests

Treatment:

Behavioral: a series of tests