Effects of Ischemic Postconditioning on MicroRNAs in Double Valve Replacement

Central South University

Status: Unknown

Conditions: Cardiopulmonary Bypass; Ischemic Postconditioning

Treatments: Device: Aortic cross-clamp; Procedure: ischemic postconditioning; Device: heart-lung machine; Procedure: double valve replacement

Study type: Interventional

Funder types: Other

Identifiers

NCT01804283

CmiR-001

Details and patient eligibility

About

1. Cardiopulmonary bypass and cardioplegic arrest could regulate expression of microRNAs in patients undergoing double valve replacement (aortic and mitral).
2. The modulation of myocardial microRNAs by cardiopulmonary bypass and cardioplegic arrest may be rescued by ischemic postconditioning.
3. Downstream effectors would also be affected.

Enrollment: 8 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Consecutive eight patients with rheumatic heart valve disease undergoing elective double valve replacement(aortic and mitral)are considered for participation in this study.

Exclusion criteria

• insulin-dependent diabetes mellitus
• pulmonary, renal, or hepatic failure
• infective valve disease
• valve disease with coronary artery disease
• hypertension
• emergency and reoperations
• received aspirin,corticosteroids, or statin preoperatively
• received preoperative inotropic support

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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8 participants in 2 patient groups

CON

Sham Comparator group

Description:

Patients undergoing double valve replacement (aortic and mitral).

Treatment:

Device: heart-lung machine

Procedure: double valve replacement

Device: Aortic cross-clamp

IPO

Experimental group

Description:

Patients undergoing double valve replacement (aortic and mitral) with ischemic postconditioning.

Treatment:

Device: heart-lung machine

Procedure: double valve replacement

Procedure: ischemic postconditioning

Device: Aortic cross-clamp