Effects of Ischemic Preconditioning After Aortic Clamping

University Hospital, Strasbourg, France

Status: Terminated

Conditions: Ischemia-reperfusion; Vascular Surgery; Ischemia Preconditioning

Treatments: Procedure: Procedure/Surgery: usual surgery; Procedure: Ischemic preconditioning during aortic clamping

Study type: Interventional

Funder types: Other

Identifiers

NCT02254642

5831

Details and patient eligibility

About

Open surgery for aneurysmal aortic disease can lead to cardiac, renal, pulmonary or muscular complications, essentially due to the aortic clamping. Ischemic preconditioning can be useful in order to decrease these complications. The investigators would like to use an ischemic preconditioning protocol during open surgery of aortic aneurysm in order to decrease these complications.

Enrollment: 59 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with an aortic aneurysm requiring open surgery (with no possibility of endovascular surgery)
• Patients who received clear information, with signed consent
• Patients 18 to 85 years

Exclusion criteria

• Patients under guardianship
• No possibility to give the patients clear information (comprehension difficulties, emergency surgery)
• Pregnancy, lactation
• Hemodialysis

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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59 participants in 2 patient groups

Ischemic preconditioning arm

Experimental group

Description:

Patients will have the ischemic preconditioning protocol 1 hour before the aortic clamping.

Treatment:

Procedure: Ischemic preconditioning during aortic clamping

Control patients

Other group

Description:

Usual surgery assigned to control patients

Treatment:

Procedure: Procedure/Surgery: usual surgery