Effects of Isoflavone Combined With Astaxanthin on Skin Aging

Seoul National University

Status: Completed

Conditions: Ageing; Photo-aging

Treatments: Dietary Supplement: Isoflavone; Dietary Supplement: Placebo; Dietary Supplement: Astaxanthin

Study type: Interventional

Funder types: Other

Identifiers

NCT02373111

H-1412-144-637

Details and patient eligibility

About

Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.

Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals.

In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively.

The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.

Enrollment: 90 patients

Sex: Female

Ages: 45+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy females aged ≥ 45 years
• Facial wrinkle grade 2 to 4

Exclusion criteria

• received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study
• received any hormone replacement therapy at least 3 months before the study
• reported taking functional foods more than 1 month during last 3 months before the study
• history of acute or chronic disease such as severe liver or kidney disease
• history of allergies against any component of trial foods
• any visible skin disease that might be confused with a skin reaction to the test procedure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 2 patient groups, including a placebo group

Isoflavone and Astaxanthin

Active Comparator group

Description:

Each subject takes one active tablet per day for 24 weeks. Each tablet contains isoflavone 27mg and astaxanthin 4mg.

Treatment:

Dietary Supplement: Isoflavone

Dietary Supplement: Astaxanthin

Placebo

Placebo Comparator group

Description:

Each subject takes one placebo tablet per day for 24 weeks.

Treatment:

Dietary Supplement: Placebo