Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

Vilnius University

Status and phase: Completed; Phase 4

Conditions: Opiate Dependence

Treatments: Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT00300794

PROT N1 V1_5

Details and patient eligibility

About

The purpose of this study is to determine whether low-dose ketamine infusion is effective in suppressing the symptoms of opiate withdrawal during rapid opiate antagonist induction (RAI).

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed opiate dependence according to ICD 10 and/or DSM 4;
• Duration of substance abuse more than 1 year
• No or minor co-morbidities;
• Grade I-II according to physical status classification system of American Society of Anesthesiologists.

Exclusion criteria

• Current history of long acting opiate or poly-substance abuse;
• Acute medical or surgical condition;
• Pregnancy;
• Breastfeeding.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind