Effects of L-Carnitine on Gastric Emptying in Children With Drug Resistant Epilepsy on Ketogenic Diet

Ain Shams University

Status: Completed

Conditions: Ketogenic Diet

Treatments: Dietary Supplement: L- Carnitine; Other: ketogenic diet

Study type: Interventional

Funder types: Other

Identifiers

NCT06255873

FMASU MS 630/ 2022

Details and patient eligibility

About

This study was conducted on thirty children aged from12 months to 18 years newly diagnosed with drug resistant epilepsy and following up at Pediatric Nutrition and Neurology Outpatient Clinics assigned randomly into 2 groups, group1: patients who started ketogenic diet with L-carnitine and group2: patients who started ketogenic diet only.

Enrollment: 30 patients

Sex: All

Ages: 12 months to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All infants and children aged from 12 months to 18 years old newly diagnosed with drug resistant epilepsy and were assigned to start KD.

Exclusion criteria

• Patients with intolerance or non-compliance to ketogenic diet therapy.
• Patients for epilepsy surgery or vagal nerve stimulation.
• Children with history of previous abdominal operations.
• Children with history of GI diseases affecting GI motility before starting KD.
• Children with tube feeding or feeding gastrostomy or jejunostomy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

ketogenic diet with L - Carnitine supplementation.

Experimental group

Description:

Patients with drug resistant epilepsy who received ketogenic diet with L - Carnitine supplementation.

Treatment:

Other: ketogenic diet

Dietary Supplement: L- Carnitine

ketogenic diet.

Active Comparator group

Description:

Patients with drug resistant epilepsy who received ketogenic diet only.

Treatment:

Other: ketogenic diet