Effects of L-carnitine Therapy on the Heart of Maintenance Hemodialysis Patients

The First Affiliated Hospital of Zhejiang Chinese Medical University

Status and phase: Completed; Phase 4

Conditions: Renal Dialysis

Treatments: Drug: Levocarnitine Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT05673239

2022-ZKNT-001

Details and patient eligibility

About

This study is intended to be a multicenter, prospective, non-randomized, controlled real-world study. Patients receiving L-carnitine injection were included in the experimental group and the control group according to whether they received L-carnitine injection. Patients receiving L-carnitine injection were included in the experimental group, and those receiving L-carnitine injection were included in the control group.To observe the effects of L-carnitine on cardiac function in hemodialysis patients.

Enrollment: 1,008 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Maintenance hemodialysis patients;
• 18 years<80 years;
• Have clear consciousness and independent behavior ability;
• Before dialysis, the total carnitine concentration was less than 40 umol/L, or the free carnitine concentration was less than 35 umol/L.

Exclusion criteria

• Acute cardiovascular and cerebrovascular diseases occurred within 1 month;
• Infectious diseases occurred within 1 month; Treatment with glucocorticoid or immunosuppressant;
• Patients who have used L-carnitine within 2 weeks.
• Hematological system tumor or tumor;

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

1,008 participants in 2 patient groups

Test group

Experimental group

Description:

The patients in the test group were injected with levocarnitine on each dialysis day, and other conventional treatment drugs such as hemodialysis drugs were maintained in the original scheme and recorded in detail on the CRF form.

Treatment:

Drug: Levocarnitine Injection

Control group

No Intervention group

Description:

The patients in the control group were the same as those in the test group, except that they were not treated with L-carnitine.