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Participants will complete five sessions, including one familiarization and baseline session and four experimental conditions (placebo, L-tyrosine, caffeine, and combined supplementation). The baseline session will include resting measurements. The experimental conditions will be performed in a randomized, counterbalanced crossover design with a washout period of at least 72 hours between sessions.
Full description
Participants will attend five sessions in total. The first session will be used for familiarization and baseline measurements, including resting physiological and cognitive assessments. The remaining four sessions will consist of randomized experimental conditions (placebo, L-tyrosine, caffeine, and combined supplementation), applied in a counterbalanced crossover design.
Each experimental session will be separated by a washout period of at least 72 hours. Supplements will be administered 60 minutes before exercise. Cognitive performance will be assessed using the Stroop test, and physical performance will be evaluated using a boxing-specific simulation protocol. Physiological responses, including heart rate and biochemical markers such as BDNF and oxidative stress parameters, will be measured.
Enrollment
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Inclusion criteria
Male elite boxers aged ≥18 years At least 8 years of boxing training experience Active participation in national or international competitions Regular training schedule No injury or illness affecting performance
Exclusion criteria
Use of nutritional supplements or stimulants within the last 4 weeks Any cardiovascular, metabolic, or neurological disorder Current injury or musculoskeletal limitation Smoking or excessive caffeine intake Failure to comply with study procedures
Primary purpose
Allocation
Interventional model
Masking
18 participants in 4 patient groups, including a placebo group
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Central trial contact
Halil UÇAR
Data sourced from clinicaltrials.gov
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