Effects of Lactobacillus Paracasei PS23 on Anti-fatigue

Chi-Chang Huang

Status: Completed

Conditions: Fatigue

Treatments: Dietary Supplement: PS23

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05346432

22-003-A2

Details and patient eligibility

About

This research is to explore the effects of supplementing Lactobacillus paracasei PS23 to reduce fatigue and improve physical fitness after exhaustive exercise.

Full description

Studies have found that the intestinal flora of athletes is different from that of ordinary people, and short-chain fatty acids play a very important role. Previous animal experiments have found that supplementing with specific probiotics can slow down muscle loss in aging mice. In addition, clinical studies have found that supplementing with probiotics can improve sports performance by regulating the intestinal flora and related metabolites. Therefore, the purpose of this research is to explore the effects of supplementing Lactobacillus paracasei PS23 to reduce fatigue and improve physical fitness after exhaustive exercise. This study compares supplementary samples with placebo and adopts a double-blind study design.

Enrollment: 120 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult men and women aged 20-40 who are generally non-athletic players

Exclusion criteria

• BMI≧27
• Known allergy to probiotics
• Have current or history of inflammatory bowel disease
• Patients using of other probiotic products (sachet, capsule or tablet) within the preceding two weeks
• Those who have taken medication such as anti-inflammatory pain killer or antibiotics in the past one month
• smoker and alcoholic
• Who have been injured within 6 months
• Who has been diagnosed and treated of cardiovascular disease, hypertension, metabolic disease, asthma, or cancer
• Have undergone surgery of liver, bladder, or gastrointestinal tract
• Who has conflict of interest with PI

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 3 patient groups, including a placebo group

PS23

Experimental group

Description:

The PS23 belongs to Lactobacillus paracasei group, 2 caps daily use.

Treatment:

Dietary Supplement: PS23

heat-treated PS23

Experimental group

Description:

PS23 heat-treated, 2 caps daily use.

Treatment:

Dietary Supplement: PS23

placebo

Placebo Comparator group

Description:

The placebo capsule contains microcrystalline cellulose, 2 caps daily use.

Treatment:

Dietary Supplement: PS23