Effects of Lactobacillus Plantarum PS128 on Symptoms of Early-onset Parkinson's Disease: a Pilot Study

Professor Lu Neurological Clinic

Status

Unknown

Conditions

Early Onset Parkinson Disease

Treatments

Dietary Supplement: PS128

Study type

Interventional

Funder types

Other

Identifiers

NCT04722198

PS128-04

Details and patient eligibility

About

This study is designed to examine L. plantarum PS128 can improve symptoms in early onset PD patients. L. plantarum PS128 is a psychobiotic that regulates the level of dopamine in specific brain regions. Patients with early onset PD will receive PS128 treatment for 12 weeks. Symptoms of PD will be clinically evaluated before and after the treatment, and the results will be compared.

Enrollment

20 estimated patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Early Onset Parkinson's Disease, EOPD
at least 9 years education
age between 20 and 80 years old

Exclusion criteria

Patients on antibiotics within the preceding one month
Patients using of other probiotic products (sachet, capsule or tablet) within the preceding two weeks
Have undergone surgery of liver, bladder, or gastrointestinal tract
Have current or history of inflammatory bowel disease
Have history of cancer
Known allergy to probiotics
Patients with comorbid dementia (Mini-Mental State Examination score ≤ 26) or major depression (The Beck Depression Inventory-II score ≥ 29)
Have received deep brain stimulation
Patients receiving artificial enteral or intravenous nutrition
Diagnosed before 40 years old
Poor control of other chronic diseases
Not eligible judged by PI