Effects of Left Atrial Appendage Resection and Marshall Ligament Amputation on Clinical Outcome in Patients Undergoing Off-pump Coronary Artery Bypass

National Center for Cardiovascular Diseases

Status: Enrolling

Conditions: Coronary Artery Disease; Atrial Fibrillation; Stroke

Treatments: Procedure: Left Atrial Appendage Resection and Marshall Ligament Amputation

Study type: Interventional

Funder types: Other

Identifiers

NCT04220047

2019-1304

Details and patient eligibility

About

Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative atrial fibrillation.New-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term and long term risk of stroke and mortality.Marshall ligament amputation may reduce the occurence of atrial fibrillation. However, little is known whether this approach is justified during the coronary artery bypass graft.Therefore, this study aimed to investigate whether LAAO and Marshall ligament amputation during off-pump coronary artery bypass was associated with reduced risks of postoperative new-onset atrial fibrillation and stroke.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• isolated first off-pump coronary artery bypass

Exclusion criteria

• Preoperative atrial fibrillation or a history of atrial fibrillation;
• Concurrent cardiac or non-cardiac surgery
• Intraoperative convert to bypass bypass surgery
• Emergency surgery
• History of previous cardiac surgery
• Severe organ dysfunction

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

400 participants in 2 patient groups

Left Atrial Appendage Resection

Experimental group

Treatment:

Procedure: Left Atrial Appendage Resection and Marshall Ligament Amputation

off-pump coronary artery bypass

No Intervention group