Effects of Left Ventricular Assist Device Implantation on the Phenotype of Blood Platelets and Leucocytes (DAV-Hémo)

Toulouse University Hospital

Status: Completed

Conditions: Cardiac Insufficiency

Treatments: Other: Blood sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT03306017

RC31/16/8258

2016-A01601-50 (Other Identifier)

Details and patient eligibility

About

To compare in vivo platelet and leukocyte activation and phenotype before and after Left ventricular assist device (LAVD) implantation

Full description

The present study plan to investigate platelet activation in vivo using a variety of biomarkers previously identified as sensitive to high shear stress in patients with severe aortic valve stenosis before and after trans arterial valve replacement. As one of the best biomarker is a high degree of platelet-leukocyte interactions, the study will study in parallel leukocytes activation/differentiation. These parameters will be compared at 3 time-points, before and after LAVD implantation in ambulatory patients.

Enrollment: 4 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective implantation of LAVD (Heartmate II),
• written informed consent to the study
• Patients with health insurance

Exclusion criteria

• treatment or procedure that could affect platelet functions or turn-over(low-dose aspirin is allowed).
• Pregnancy or breastfeeding
• Juridical Protection

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

4 participants in 1 patient group

LAVD implantation

Experimental group

Description:

Ten patients before and after LAVD implantation had blood sampling

Treatment:

Other: Blood sampling