Effects of LH and FSH on Metabolic Regulation in Cumulus Cells

Kaohsiung Veterans General Hospital

Status: Enrolling

Conditions: Unrecognized Condition

Treatments: Drug: FSH and LH; Drug: FSH

Study type: Interventional

Funder types: Other

Identifiers

NCT06803199

KSVGH24-CT7-22

Details and patient eligibility

About

The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear. This prospective study will examine how FSH and LH combined treatment affects cumulus cell energy metabolism. Sixty participants will be divided into two groups receiving either combined therapy or FSH alone. The study will analyze patient characteristics, infertility history, and compare mitochondrial function in cumulus cells to evaluate treatment effectiveness.

Full description

The impact of combined follicle-stimulating hormone (FSH) and luteinizing hormone (LH) treatment on ovulation stimulation in older infertile women has garnered significant attention in reproductive medicine. While research indicates improved in vitro fertilization (IVF) pregnancy rates in women aged 35-40 receiving combined FSH and LH therapy compared to FSH alone, the underlying mechanisms and effectiveness remain unclear. This prospective study aims to investigate the effects of combined FSH and LH treatment on cumulus cell energy metabolism in infertile women aged 35-40 undergoing IVF treatment. The research will involve 60 participants divided into two equal groups: one receiving combined FSH and LH therapy and the other receiving FSH alone. The study will collect comprehensive data including baseline characteristics, infertility history, ovarian function parameters, and ovulation stimulation cycle outcomes. Additionally, cumulus cells will be collected from both groups to compare their mitochondrial metabolic function. Through this investigation, we seek to understand whether the combined hormone approach can enhance cumulus cell energy metabolism and improve overall ovulation stimulation outcomes in this specific age group. CopyRetryClaude can make mistakes. Please double-check responses.

Enrollment: 60 estimated patients

Sex: Female

Ages: 35 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 35-40 years
• BMI 18-30 kg/m2
• planning to undergo IVF cycles

Exclusion criteria

• Primary ovarian insufficiency
• history of oophorectomy
• receiving oocyte donation
• Chromosome anomaly
• Congenital uterine anomaly
• Severe intrauterine adhesion
• Malignancy
• Using hormone therapy or supplements in recent 3 months

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

combined FSH and LH

Experimental group

Description:

Participants receive combined FSH and LH during controlled ovarian stimulation in IVF cycle

Treatment:

Drug: FSH and LH

FSH alone

Active Comparator group

Description:

Participants receive combined FSH and LH during controlled ovarian stimulation in IVF cycle

Treatment:

Drug: FSH