Effects of Ligands on Human Hair Follicles Grafted Onto SCID Mice

Hordinsky, Maria K., MD

Status and phase: Completed; Phase 1

Conditions: Alopecia

Treatments: Drug: FK506, GP11046, GP11511

Study type: Interventional

Identifiers

NCT00177099

0306M49486

Details and patient eligibility

About

The purpose of this study is to determine if immunophilin ligands may have the potential to reverse hair loss.

Full description

Preliminary experiments in C57BL/6J mice showed that immunophilin ligand FK506 and its non-immunosuppressive analogs, GP11046 and GP11511 were capable of promoting telogen to anagen transition. Since GP11046 and GP11511 possess the neurotrophic properties of FK506 without its immunosuppressant capability, the neural action of these immunophilin ligands may play an important role in the hair cycle. This finding has significant clinical implications in that immunophilin ligands may have the potential to reverse alopecia. To further investigate this possibility we propose to explore the response of transplanted miniaturized scalp hair follicles to topically applied immunophilin ligands.

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men ages 18-65 with Hamilton type IV or V alopecia

Exclusion criteria

• Individuals who do not meet the inclusion criteria.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)