Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

Virginia Commonwealth University (VCU)

Status and phase: Completed; Phase 2; Phase 1

Conditions: Healthy

Treatments: Drug: Levothyroxine; Drug: Placebos; Drug: Liothyronine

Study type: Interventional

Funder types: Other

Identifiers

NCT03098433

HM20005777

Details and patient eligibility

About

This study will assess the short term effects of a single dose of liothyronine on the cardiovascular system and energy expenditure

Enrollment: 22 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI >20<30 kg/m2
• TSH >0.5<5.0 mcIU/mL
• Negative TPO antibodies

Exclusion criteria

• Pregnancy
• Use of prescription drugs
• Diabetes mellitus
• Coronary artery disease
• Hypertension
• Anemia
• Renal insufficiency
• Liver disease or ALT >2.5 x the upper laboratory reference limit

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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22 participants in 3 patient groups, including a placebo group

Liothyronine

Experimental group

Description:

Each participant will receive a single dose of lithyronine

Treatment:

Drug: Liothyronine

Levothyroxine

Active Comparator group

Description:

Each participant will receive a single dose of levothyroxine

Treatment:

Drug: Levothyroxine

Placebo

Placebo Comparator group

Description:

Each participant will receive a single dose of placebo

Treatment:

Drug: Placebos