Effects of Long Term Calorie Restriction on Sphingomyelin and Amino Acids

Yonsei University

Status and phase: Completed; Phase 3

Conditions: Obese; Overweight

Treatments: Dietary Supplement: LCD

Study type: Interventional

Funder types: Other

Identifiers

NCT02081898

wt loss_20140305

Details and patient eligibility

About

The effect of weight loss with long-term low calorie diet (LCD) on plasma metabolites is unknown. The aim was to examine whether a LCD-induced weight reduction results in changes in the extended plasma metabolites.

Full description

Overweight/obese subjects (25≤ BMI <33 kg/m2) aged 40 to 59 years consumed a LCD (an approximate 100 kcal/day calorie deficit) or a weight-maintenance diet (control) in a randomized, controlled design with 3-year intervention period.

Enrollment: 120 patients

Sex: All

Ages: 40 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 25 <= BMI < 33 kg/m2

Exclusion criteria

• type 2 diabetes
• cardiovascular disease
• psychiatric problems
• any medication use

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 2 patient groups

control group

No Intervention group

Description:

weight maintenance diet

low calorie diet (LCD) group

Experimental group

Description:

approximate 100 kcal/d calorie deficit

Treatment:

Dietary Supplement: LCD