Effects of Low Calorie Sweeteners on Dietary Intakes, Hunger, Appetite and Satiety

Coca-Cola

Status

Completed

Conditions

Eating Behavior

Treatments

Other: Still water

Other: Beverage containing low calorie sweeteners

Study type

Interventional

Funder types

Industry

Other

Identifiers

NCT02297880

CreaBIO1

Details and patient eligibility

About

Although there is evidence that low calorie sweeteners (LCS) do not stimulate hunger or appetite, divergent opinions appear regularly both in the scientific literature and in the popular press. The goal of this study is to examine the effects of LCS containing beverages on appetite and intake in healthy individuals.

Full description

The study will be a monocentric randomized controlled open trial including two parallel groups to examine effects of LCS beverages as compared to water on daily intakes of energy and macronutrients. The effects of LCS beverages on hunger, satiety, desire to eat and on the selection of sweet or savory foods eating occasions will be assessed.

Enrollment

170 patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Body Mass Index: Lower limit 18 kg/m²; Upper limit 28 kg/m²; weight stable within ± 3 kg in the last 6 months
Habitual energy intake within the 95% confident interval of the reference energy intake for the French population (as provided by the INCA 2 survey
Must not be a regular drinker of LCS beverages (less than once a week no more than every 15 days) and be willing to use LCS according to protocol
For female participants: not pregnant, not breast feeding, planning to become pregnant during the study or on contraception since at least 3 months (regular 28-day cycle)
Subject registered with the French Social Security.

Exclusion criteria

Currently diagnosed somatic pathology
On medication affecting metabolism, weight, energy intake, or energy expenditure in the last 6 months
Major psychiatric disorder, particularly eating disorders as defined by the Diagnostic and Statistical Manual od Mental Disorders-IV
Rejection of sweet foods or drinks as revealed by the diet history
Smoking subject planning to stop smoking in the next 3 months
Subjects suffering from food allergies or intolerance
Subject not capable of understanding the constraints of the study and who not agree to abide