Effects of Low- or High-glycemic Index Diets on Metabolic and Inflammatory Responses in Diabetics

Federal University of Vicosa

Status: Completed

Conditions: Type 2 Diabetes Mellitus

Treatments: Dietary Supplement: High GI diet; Dietary Supplement: Low GI index diet

Study type: Interventional

Funder types: Other

Identifiers

NCT02383784

40501156099

Details and patient eligibility

About

Background/Aims: Verify the effects of glycemic index (GI) on body composition, and on inflammatory and metabolic markers concentrations. Methods: Eighteen type 2 diabetics, (aged 42.4 + 5.1 years, BMI 29.2 + 4.8 kg.m-2) were randomly allocated to low GI (LGI) or high GI (HGI) groups. High or low GI meals were provided in the laboratory twice a day during 30 consecutive days. The other meals were consumed under free living condition and subjects were instructed to select foods presenting GI values corresponding to the allocated group. Body composition (body mass index, body fat percentage, waist circumference and waist-hip ratio), and inflammatory markers concentrations (interleukin-6, tumor necrosis factor-alpha, high molecular weight adiponectin, ultra-sensitive C-reactive protein and fibrinogen) and metabolic markers (glucose, insulin, total cholesterol, HDL cholesterol, free fatty acids, triglycerides and fructosamine) were assessed at baseline and after intervention. Food intake was monitored during the study. The criterion for statistical significance was P<0.05.

Enrollment: 18 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetes mellitus
• Level of physical activity light to moderate
• Use of sulfonylureas or biguanides oral hypoglycemic drugs
• Stable medications for the previous 3 months

Exclusion criteria

• Cardiovascular, renal, or liver disease
• Treatment for cancer
• Smokers
• Daily consumption of > 50g/day of alcohol
• Pregnant, lactating, postmenopausal women,
• Hormone replacement therapy
• Recent change (last three months) in the level of physical activity or diet
• Weight instability (> 3 kg in the previous three months),
• Therapeutic diet
• Allergies, test foods intolerance
• Use of drugs affecting body metabolism and/or food intake.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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18 participants in 2 patient groups

Low-GI diet

Experimental group

Description:

Low glycemic index diet

Treatment:

Dietary Supplement: Low GI index diet

High-GI diet

Experimental group

Description:

High glycemic index diet

Treatment:

Dietary Supplement: High GI diet