Effects of LPG and Ventilation Interventions on Reducing HAP and Improving Cardiopulmonary Health

Huazhong University of Science and Technology

Status: Enrolling

Conditions: Cardiopulmonary Function; Environmental Exposures

Treatments: Behavioral: Using liquefied gas for cooking; Device: Using rang hood during cooking

Study type: Interventional

Funder types: Other

Identifiers

NCT07005193

2023ZD0509900

Details and patient eligibility

About

The goal of this clinical trial is to evaluate the independent and synergistic effects of liquefied petroleum gas (LPG) substitution and improved ventilation on household air pollution (HAP) reduction and cardiopulmonary health. The main questions it aims to answer are:

1. Does LPG substitution or improved ventilation reduce HAP and improve cardiopulmonary health?
2. Would the combined intervention of LPG substitution and improved ventilation outperform single interventions?
3. What is the cost-effectiveness of such interventions, and are they sustainable?

Participants will be randomized in 4 groups:

A: Solid fuel + no ventilation facilities group (195 households): Continued use of solid fuels without ventilation facilities, with a one-time financial compensation provided post-intervention; B: Liquefied petroleum gas (LPG) + no ventilation facilities group (195 households): Provided with LPG stoves and instructed to use them for cooking, with regular LPG supply during the intervention period; C: Solid fuel + ventilation facilities group (195 households): Maintained solid fuel usage habits while provided with ventilation facilities and instructed to use them during cooking, with electricity costs compensated during the intervention; D: LPG + ventilation facilities group (195 households): Provided with both LPG stoves and ventilation facilities, instructed to use both during cooking, with regular LPG supply and electricity cost compensation throughout the intervention period.

Enrollment: 780 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

1. Inclusion Criteria Primary Participants：

   • Primary use of solid fuels (coal, wood, charcoal, or crop residues) for cooking;
   • Kitchen is suitable for installing ventilation facilities;
   • The main cook in the household (cooking frequency ≥5 times/week);
   • Aged between 18 and 74 years;
   • Local permanent residents with no plans for long-term travel or relocation within one year.

   Secondary Participants

   ● Elderly individuals aged 65-74 who lived with the included primary participants.

2. Exclusion Criteria:

   • Clinical diagnosis of major chronic diseases such as severe respiratory diseases, cardiovascular diseases, malignant tumors, or end-stage renal disease;
   • Pregnant or breastfeeding women;
   • Current smokers or individuals with self-reported exposure to productive dust or other occupational hazards;
   • Individuals who are unable to fully understand the study process or clearly express their own complaints, such as those with psychiatric disorders or severe neuroses, or who cannot cooperate with the study for other reasons.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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780 participants in 4 patient groups

A: Solid fuel + no ventilation (control).

No Intervention group

Description:

Solid fuel + no ventilation facilities group: Continued use of solid fuels without ventilation facilities, with a one-time financial compensation provided post-intervention.

B: LPG + no ventilation.

Experimental group

Description:

Liquefied petroleum gas (LPG) + no ventilation facilities group: Provided with LPG stoves and instructed to use them for cooking, with regular LPG supply during the intervention period.

Treatment:

Behavioral: Using liquefied gas for cooking

C: Solid fuel + ventilation.

Experimental group

Description:

Solid fuel + ventilation facilities group: Maintained solid fuel usage habits while provided with ventilation facilities and instructed to use them during cooking, with electricity costs compensated during the intervention.

Treatment:

Device: Using rang hood during cooking

D: LPG + ventilation.

Experimental group

Description:

LPG + ventilation facilities group: Provided with both LPG stoves and ventilation facilities, instructed to use both during cooking, with regular LPG supply and electricity cost compensation throughout the intervention period.

Treatment:

Device: Using rang hood during cooking

Behavioral: Using liquefied gas for cooking