Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population

The Hong Kong Polytechnic University

Status: Completed

Conditions: Lens Opacity

Treatments: Dietary Supplement: Starch; Dietary Supplement: Lycium Barbarum

Study type: Interventional

Funder types: Other

Identifiers

NCT01142960

5-ZH73

Details and patient eligibility

About

With the rapid growing aging population, age-related eye diseases including cataract are becoming more prevalent. The demand for cataract surgery and post-surgical care posed enormous financial burdens to the government.

Lycium barbarum contains lutein and zeaxanthin which can filter the phototoxic blue light and neutralize the reactive oxygen species, thus provide a protective effect against cataract formation.

This study aims to determine the effects of Lycium barbarum Supplements on the progression of senile cataract in Hong Kong Chinese elderly.

Full description

Please note that a manuscript for this study is being prepared. Detailed description will be provided after we come up with the final draft.

Enrollment: 238 patients

Sex: All

Ages: 60 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Unlikely to have cataract surgery within 3 years
• Presence of mild to moderate cataract in one or both eyes, graded by Lens Opacities Classification System III (LOCSIII).
• logMAR acuity equivalent to Snellen acuity of 20/63 or better
• no previous history and clinical signs of glaucoma by determining intraocular pressure using applanation Tonometry (no more than 22mmHg)
• no ocular anomalies: amblyopia, binocular anomalies, ocular trauma
• no history of eye surgery, laser treatment, iritis, retinal crystalline deposits, macular degeneration, or optic nerve diseases
• no extended use of systemic or ocular corticosteroid drugs
• no concurrent participation of other systemic or ocular drug intervention study

Exclusion criteria

• diabetes mellitus
• renal failure
• fat malabsorption syndrome
• intestinal surgery history
• chronic diarrhea
• alcoholism
• use of anticoagulants
• regular use of nutritional supplements such as multi-vitamin, mineral and other antioxidant supplements (including Omega-3)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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238 participants in 2 patient groups

Placebo

Active Comparator group

Description:

Starch

Treatment:

Dietary Supplement: Starch

Lycium Barbarum

Experimental group

Description:

Lycium Barbarum supplement

Treatment:

Dietary Supplement: Lycium Barbarum