Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium

Seoul National University

Status: Completed

Conditions: Surgical Condition; Observation of Neuromuscular Block; Intubation Condition

Treatments: Drug: saline; Drug: magnesium sulfate 30 mg/kg

Study type: Interventional

Funder types: Other

Identifiers

NCT02100293

B-1307/209-006

Details and patient eligibility

About

This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition.

Enrollment: 84 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-75 yr American Society of Anesthesiologists physical status 1 or 2, BMI of 20-24.9 kg/m2 scheduled for elective laryngeal microsurgery

Exclusion criteria

• severe respiratory or cardiac disease hepatic or renal function impairment neuromuscular disease on medications affecting neuromuscular function with known allergy to the drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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84 participants in 3 patient groups

standard dose rocuronium group

Active Comparator group

Description:

pretreatment of saline 100ml and rocuronium 0.6 mg/kg

Treatment:

Drug: saline

low dose rocuronium group

Active Comparator group

Description:

pretreatment of saline 100ml and rocuronium 0.45 mg/kg

Treatment:

Drug: saline

low dose rocuronium plus magnesium group

Active Comparator group

Description:

pretreatment of magnesium sulfate 30 mg/kg and rocuronium 0.45 mg/kg

Treatment:

Drug: magnesium sulfate 30 mg/kg