Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women

Integrative Skin Science and Research

Status: Unknown

Conditions: Photoaging

Treatments: Other: Food

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT04869852

MANGO_02

Details and patient eligibility

About

Mangos are a rich source of nutrients such as carotenoids, vitamin C and fiber, as well as polyphenols and phenolic acids such as mangiferin, ellagic acid, and gallotannins. Mango extract has been reported to protect against photo-aging of the skin in an animal model exposed to UVB radiation, reducing the length of wrinkles and increasing collagen bundles. Beta-carotene and other carotenoids are known to provide skin protection from sunlight, but other compounds in mangos, may also be important in reducing oxidative damage in aging skin.

We have recently completed a pilot study showing a clear trend in skin wrinkle reduction when postmenopausal women consumed 85g of Ataulfo mangos, four times per week for 16 weeks. To confirm and extend these results, a larger study is proposed.

Enrollment: 70 estimated patients

Sex: Female

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 50 - 70 years old
• Postmenopausal
• Fitzpatrick skin type I, II, or III
• BMI 18.5 - 35
• Must be willing to comply with all protocol requirements
• Must be willing to have flash photo facial images taken with the imaging systems

Exclusion criteria

• Smokers
• Allergy to mangos
• Vegans/vegetarians
• Adults unable to consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

Mango

Experimental group

Description:

85g mango, 4x/week

Treatment:

Other: Food

No Mango

No Intervention group

Description:

No mango intake