Effects of Mental Stimulation in Patients With Mild Cognitive Impairment

Johns Hopkins University

Status and phase: Completed; Phase 2

Conditions: Mild Cognitive Impairment (MCI)

Treatments: Behavioral: mentally stimulating activities

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01212692

R01AG034934 (U.S. NIH Grant/Contract)

NA_00039100

Details and patient eligibility

About

The purpose of this study is to learn if activities that challenge the brain (mentally stimulating activities) can improve memory and other types of thinking in patients with Mild Cognitive Impairment. The study will compare the effects of different methods of mental stimulation.

Enrollment: 63 patients

Sex: All

Ages: 50 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥ 50 years of age
• meet criteria for amnestic-Mild Cognitive Impairment (MCI)
• have capacity to give informed consent
• have capacity to complete assessment measures

Exclusion criteria

• history of drug or alcohol dependence
• severe psychiatric conditions associated with psychosis (e.g., schizophrenia)
• recent stroke
• clinical diagnosis of probable Alzheimer's Disease
• history of seizure disorder, serious head trauma, or other medical, psychiatric, or neurological conditions associated with significant cognitive impairment (e.g., Parkinson's Disease, Korsakoff's, HIV)
• current use of Alzheimer's Disease medications (e.g., cholinesterase inhibitors, memantine)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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63 participants in 2 patient groups

Mentally stimulating activities

Experimental group

Treatment:

Behavioral: mentally stimulating activities

Mentally stimulating activities- other

Active Comparator group

Treatment:

Behavioral: mentally stimulating activities