Effects of Menthol on Dyspnoea in COPD Patients (MEDiC)

G

Groupe Hospitalier du Havre

Status

Completed

Conditions

Dyspnea
Lung Diseases
Copd

Treatments

Other: Test with Menthol
Other: Test with placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT03626519
2018-A00585-50

Details and patient eligibility

About

Chronic obstructive pulmonary disease (COPD) is characterised by non-reversible bronchial obstruction associated with systemic disorders and comorbid factors. Dyspnoea is a common symptom among patients with Chronic Obstructive pulmonary Disease (COPD). Dyspnea is the primary symptom limiting exercise and daily activities in these patients. It has been reported that breathing cold air could decrease dyspnoea induced by exercise and could improve exercise performance. The aim of this study is to carry out the effect of cooling sensation induced by menthol chewing-gum on dyspnoea and exercise performance among patients with COPD.

Enrollment

63 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • a diagnosis of COPD
  • Dyspnea in daily living (2-4 on the modified medical research council dyspnea scale)
  • Clinically stable

Exclusion criteria

  • exercise contraindication Any musculoskeletal problems, cardiovascular or neurological comorbidities that limits exercise.
  • exacerbation during the study
  • Inability to chew or patients with swallowing disorders

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

63 participants in 2 patient groups, including a placebo group

Test with Menthol
Experimental group
Description:
Patients will chew a menthol flavored chewing gum 5 minutes before perform one Six-minute Walk Test
Treatment:
Other: Test with Menthol
Test with placebo
Placebo Comparator group
Description:
Patients will chew a strawberry flavored chewing gum 5 minutes before perform one Six-minute Walk Test
Treatment:
Other: Test with placebo

Trial contacts and locations

3

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Data sourced from clinicaltrials.gov

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