Effects of Menthol on Dyspnoea in COPD Patients (MEDiC)

Groupe Hospitalier du Havre

Status: Completed

Conditions: Dyspnea; Lung Diseases; Copd

Treatments: Other: Test with Menthol; Other: Test with placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03626519

2018-A00585-50

Details and patient eligibility

About

Chronic obstructive pulmonary disease (COPD) is characterised by non-reversible bronchial obstruction associated with systemic disorders and comorbid factors. Dyspnoea is a common symptom among patients with Chronic Obstructive pulmonary Disease (COPD). Dyspnea is the primary symptom limiting exercise and daily activities in these patients. It has been reported that breathing cold air could decrease dyspnoea induced by exercise and could improve exercise performance. The aim of this study is to carry out the effect of cooling sensation induced by menthol chewing-gum on dyspnoea and exercise performance among patients with COPD.

Enrollment: 63 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• a diagnosis of COPD
• Dyspnea in daily living (2-4 on the modified medical research council dyspnea scale)
• Clinically stable

Exclusion criteria

• exercise contraindication Any musculoskeletal problems, cardiovascular or neurological comorbidities that limits exercise.
• exacerbation during the study
• Inability to chew or patients with swallowing disorders

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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63 participants in 2 patient groups, including a placebo group

Test with Menthol

Experimental group

Description:

Patients will chew a menthol flavored chewing gum 5 minutes before perform one Six-minute Walk Test

Treatment:

Other: Test with Menthol

Test with placebo

Placebo Comparator group

Description:

Patients will chew a strawberry flavored chewing gum 5 minutes before perform one Six-minute Walk Test

Treatment:

Other: Test with placebo