Effects of Milk Protein Concentrate on Overall Health During Weight Loss in Overweight/Obese Adults (S28)

Purdue University

Status: Completed

Conditions: High Blood Pressure; Metabolic Disease; Sarcopenia

Treatments: Other: Energy Restriction

Study type: Interventional

Funder types: Other

Identifiers

NCT01692860

1109011319

Details and patient eligibility

About

. The purpose of this study is to examine the effects of eating a larger amount of dairy-based protein on risk factors for metabolic syndrome

Full description

Currently, over 47 million adults in the United States are known to have metabolic syndrome. Metabolic syndrome is comprised of a cluster of conditions including obesity, elevated cholesterol, high blood sugar, and high blood pressure. People with metabolic syndrome have an increased risk for the development of chronic diseases such as cardiovascular disease and diabetes. Recent studies have shown that a build-up of fat in the muscle of overweight and obese people may partially explain the link between metabolic syndrome and the development of chronic diseases. There is evidence to suggest that diets with a higher amount of protein can improve some aspects of metabolic syndrome, including the build-up of fat in muscle. The purpose of this study is to examine the effects of eating a larger amount of dairy-based protein on risk factors for metabolic syndrome.

Enrollment: 48 patients

Sex: All

Ages: 35 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

BMI: 25-38 ,male or female; age 35-65 y; weight stable (± 3 kg) during last 3 months; no acute illness; not diabetic, pregnant or lactating; not currently (or within last 3 months) following an exercise or weight loss program; non-smoking; not taking BP medication; not lactose intolerant,

Exclusion criteria

Subjects will be excluded if baseline protein intake is less than 0.6 or greater than 1.6 g•kg-1•d-1 Subjects will also be excluded if they have any chronic or acute condition which will increase risk of illness or injury during study participation as determined by our study physician such as high BP, high fasting glucose, metabolic syndrome, etc.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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48 participants in 2 patient groups, including a placebo group

High protein consumption

Experimental group

Description:

Intervention, energy restriction. This arm has a dietary protein intake of 1.5g/kg/d

Treatment:

Other: Energy Restriction

Normal protein consumption

Placebo Comparator group

Description:

Intervention, energy restriction. This arm has a dietary protein intake of .8g/kg/d

Treatment:

Other: Energy Restriction