Effects of Mindfulness-based Intervention on Epigenetic Mechanisms, Cognition Function, Stress Response, and Well-being

University of Sao Paulo General Hospital

Status: Completed

Conditions: Learning and Memory; DNA Methylation; Mindfulness; Psychological Well-being; Stress

Treatments: Other: Active control; Other: Mindfulness meditation training

Study type: Interventional

Funder types: Other

Identifiers

NCT05085847

3.159.669

Details and patient eligibility

About

The purpose of this study is to assess the effect of a mindfulness-based intervention on DNAmethylation, cognitive functions, stress response, and well-being in healthy female adults.

Full description

After being informed about the study and potential risks, all volunteers giving written informed consent will undergo a 1-3 week screening period to determine eligibility for study entry. At week 0, volunteers who meet the eligibility requirements will be randomized in a 1:1 ratio to the active control group (8-week, 2 hours/week of lectures) or mindfulness-based intervention (8-week, 2 hours/week of mindfulness meditation training).

Enrollment: 100 patients

Sex: Female

Ages: 23 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• (1) Brazilian male or female aged between 23 and 65 years and (2) currently working in the classroom

Exclusion criteria

1. clinical diagnosis of depression
2. clinical diagnosis of anxiety disorders
3. clinical diagnosis of schizophrenia
4. report of an infectious condition in the last 15 days before collecting a blood sample;
5. had previously practiced or currently practicing meditation, yoga or Tai-Chi.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Mindfulness-based intervention (MBI)

Experimental group

Description:

Participants received mindfulness training for 8 weeks (two-hour meetings; 16 hours total)

Treatment:

Other: Mindfulness meditation training

Active control group

Active Comparator group

Description:

Participants received lectures for 8 weeks (two-hour meetings; 16 hours total)

Treatment:

Other: Active control