Effects of Minocycline on Cytokine Levels in Severe Meibomian Gland Dysfunction

Yonsei University

Status: Completed

Conditions: Meibomian Gland Dysfunction

Treatments: Drug: oral minocycline hydrochloride treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT01600625

4-2011-0830

Details and patient eligibility

About

One of the important factors in obtaining successful outcomes when treating severe meibomian gland dysfunction (MGD) is to control the existing ocular and eyelid inflammation. Thus, in previous studies, topical and systemic antibiotics with anti-inflammatory function, such as topical azithromycin, systemic tetracycline, doxycycline and minocycline, have been used to treat severe MGD. In this study, minocycline which had the fewest side effects was used to evaluate the effect on cytokine levels in severe MGD. At study initiation, all patients completed an Ocular Surface Disease Index (OSDI) questionnaire and had an ocular surface, tear, and meibomian gland evaluation that consisted of fluorescein tear break-up time (TBUT), Schirmer test, corneal and conjunctival fluorescein staining, microscopic examination of lid margins and meibomian glands, and tear cytokine levels. All measurements except tear cytokine levels were conducted in the same manner before treatment, after 1 month, and after 2 months of treatment. Tear cytokine levels were evaluated before treatment and after 2 months of treatment. The aim of this research was to determine the concentration of inflammatory cytokines in the tears of patients with MGD and to compare the cytokine levels, corresponding clinical responses, and ocular symptoms before and after 2 months of treatment with oral minocycline.

Enrollment: 46 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with stage 3 or 4 meibomian gland dysfunction
• moderate or marked symptoms of ocular discomfort, itching, or photophobia with limitations of activities
• moderate or severe meibomian gland dysfunction clinical signs
• mild to moderate conjunctival and peripheral corneal staining or increased conjunctival and corneal staining, including central staining
• increased signs of inflammation : moderate or severe conjunctival hyperemia, phlyctenulae

Exclusion criteria

• history of previous ocular or intraocular surgery
• evidence of acute or chronic infections or inflammation of the cornea and conjunctiva
• ocular allergy
• autoimmune disease
• history of intolerance or hypersensitivity to any component of the study medications
• use of topical ocular medications
• wearing contact lenses during the study period
• presence of current punctal occlusion
• pregnancy
• lactating women
• children

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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46 participants in 1 patient group

Minocycline treatment group

Experimental group

Treatment:

Drug: oral minocycline hydrochloride treatment