Effects of Mode of Contraction on Neuromuscular Fatigue (DYN-AGING)

Centre Hospitalier Universitaire de Saint Etienne

Status: Terminated

Conditions: Volunteers

Treatments: Diagnostic Test: Isometric BW-QIF Test (Body weight-based quadriceps intermittent fatigue test); Diagnostic Test: Timed up and go; Diagnostic Test: 6 Minutes Walk Test; Behavioral: Mini Mental State Examination; Diagnostic Test: Isokinetic Body weight-based quadriceps intermittent fatigue test (BW-QIF Test); Diagnostic Test: Cycloergometer body weight-based quadriceps intermittent fatigue test (BW-QIF Test)

Study type: Interventional

Funder types: Other

Identifiers

NCT04516538

2020-A00016-33 (Other Identifier)

19CH178

Details and patient eligibility

About

Aging is associated with multiple deteriorations of the neuromuscular system. Given the increase in life expectancy, the investigators can now distinguish old adults (>60 years old) who conserve their neuromuscular capacities with regular physical activity and very old adults (>80 years old) who suffer from an inexorable decline, even if the number of octogenarians and their quality of life are progressively increasing. However, the most part of the literature on fatigue and neuromuscular capacity with aging focused on isometric tasks. The results showed a significant decrease in maximal force production capacity and a greater resistance to fatigue for old people compared to the young population. When fatigue is induced trough dynamic contractions, greater fatigability was observed in old adults compared to young adults. Investigations performed on the population aged over 80 years old are rare, showing greater fatigability in octogenarians than old men (aged 60-80 years old) during isometric tasks. The knowledge about the effects of dynamic contractions in this population are limited, and performed uniquely in single leg isokinetic mode. Evaluations that require the use of both legs and higher muscle mass involved in the task (cycloergometer) are needed. Understanding neuromuscular fatigue and fatigability across different exercise modalities is necessary to set adapted physical activity programs aimed to maintain autonomy in older individuals.

Enrollment: 65 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Belong to a defined age group: young (18 to 35 years old inclusive), old (60 to 80 years old inclusive) and very old (81 to 95 years old inclusive),
• Signed written consent form
• Being affiliated to social security

Exclusion criteria

• Pathology or surgery resulting in a locomotor disorder, within 6 months prior to the study,
• Chronic neurological, motor or psychological pathologies
• Use of neuro-active substances likely to alter cortico-spinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) for the duration of the study.
• Contraindication to magnetic stimulation:
• Cardiac or respiratory insufficiency.
• Cardiac pacemaker.
• Cardiac valve wear and serious cardiovascular diseases.
• Presence of prosthetic material or ferromagnetic foreign bodies in the head.
• Presence of cochlear implants or ocular prosthetic material.
• History of neurosurgical interventions.
• Neurological diseases that may affect brain structures and cognitive abilities (e.g., intracranial tumour, multiple sclerosis, history of stroke or traumatic brain injury).
• History of comitiality, contralateral knee pathology or pathology of the musculoskeletal system.
• Mini Mental State Examination < 20

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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65 participants in 3 patient groups

Young people

Experimental group

Description:

Men or Women under 35 years old

Treatment:

Diagnostic Test: Cycloergometer body weight-based quadriceps intermittent fatigue test (BW-QIF Test)

Diagnostic Test: Isokinetic Body weight-based quadriceps intermittent fatigue test (BW-QIF Test)

Diagnostic Test: 6 Minutes Walk Test

Diagnostic Test: Isometric BW-QIF Test (Body weight-based quadriceps intermittent fatigue test)

Diagnostic Test: Timed up and go

Old people

Experimental group

Description:

Men or Women between 60 and 80 years old

Treatment:

Diagnostic Test: Cycloergometer body weight-based quadriceps intermittent fatigue test (BW-QIF Test)

Diagnostic Test: Isokinetic Body weight-based quadriceps intermittent fatigue test (BW-QIF Test)

Diagnostic Test: 6 Minutes Walk Test

Diagnostic Test: Isometric BW-QIF Test (Body weight-based quadriceps intermittent fatigue test)

Diagnostic Test: Timed up and go

Very old people

Experimental group

Description:

Men or Women over 80 years old

Treatment:

Diagnostic Test: Cycloergometer body weight-based quadriceps intermittent fatigue test (BW-QIF Test)

Diagnostic Test: Isokinetic Body weight-based quadriceps intermittent fatigue test (BW-QIF Test)

Behavioral: Mini Mental State Examination

Diagnostic Test: 6 Minutes Walk Test

Diagnostic Test: Isometric BW-QIF Test (Body weight-based quadriceps intermittent fatigue test)

Diagnostic Test: Timed up and go