Effects of Moderate Physical Activity on Early Symptoms of Peripheral Diabetic Neuropathy in Type-II Diabetes: A Randomized Clinical Trial

Riphah International University

Status: Completed

Conditions: Peripheral Diabetic Neuropathy

Treatments: Other: Moderate Physical Activity for Peripheral Diabetic Neuropathy

Study type: Interventional

Funder types: Other

Identifiers

NCT05491850

RIPHAH/FR&AHS/Letter-0985

Details and patient eligibility

About

This study determines the effects of moderate physical activity on early symptoms of peripheral diabetic neuropathy in type-II diabetes. Most of the literature shows the impact of physical activity to manage/controlling diabetes. Some studies were conducted on animals to study the impact of physical activity on diabetic neuropathy and neurogenesis. There is no study on the impact of physical activity to manage early symptoms of peripheral diabetic neuropathy in patients with type-II diabetes in humans. This study finds the impact of moderate physical activity to manage early symptoms of peripheral diabetic neuropathy in patients with type-II diabetes in humans.

Enrollment: 17 patients

Sex: All

Ages: 35 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with Type-II Diabetes
• Diagnosed cases of Peripheral Diabetic Neuropathy
• Peripheral Diabetic Neuropathy Stage 1 & 2
• Numbness or reduced ability to feel pain or temperature changes.
• Tingling or burning sensation.
• Sharp pains or cramps.
• Increased sensitivity to touch
• Males and females
• Age: 35-65
• HbA1c above 6.5
• Mild activity level on IPAQ-7 (< 150min/per week)
• Berg Balance Scale score (< 45)

Exclusion criteria

• Cardiac Issues
• Any neurological issue
• Lower limb deformity
• Acute injury
• Hip and Knee OA
• Patients with walking difficulty
• Diabetic foot

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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17 participants in 2 patient groups

Moderate Physical Activity Group

Experimental group

Description:

The Experimental Group gets moderate physical activity. Elliptical will be performed at least 5 days/per week. Moderate intensity, corresponding approximately to 40-60% of Vo2max (maximal aerobic capacity) 150 min/week of exercise undertaken at moderate intensity or greater. Warm-up and Dynamic stretching is given before and static stretching is given after moderate physical activity.

Treatment:

Other: Moderate Physical Activity for Peripheral Diabetic Neuropathy

Non Specific Physical Activity Group

No Intervention group

Description:

The Control group continues their regular medication for diabetic neuropathy.