Effects of Morphine Added to Bupivacaine in Transversus Abdominis Plane Block for Inguinal Hernia Repair

B.P. Koirala Institute of Health Sciences

Status: Completed

Conditions: Inguinal Hernia

Treatments: Combination Product: bupivacaine and morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT05379374

IRC/1182/017

Details and patient eligibility

About

This study is conducted to determine whether morphine added to bupivacaine in ultrasound guided (USG) transversus abdominis plane (TAP) block has beneficial effects than bupivacaine alone in providing postoperative analgesia for inguinal hernia surgery.

Full description

Total of forty adult patients of American Society of Anaesthesiologists (ASA) physical status ( PS) I - II scheduled for elective inguinal hernia surgery under spinal anaesthesia were recruited in this study after getting written informed consent. They were randomized to undergo ipsilateral USG TAP block with 20 ml of 0.25 % bupivacaine (group B) versus 20 ml of 0.25 % bupivacaine with 3 mg morphine (group BM). Patients were followed postoperatively for the 24 hours by a blinded investigator for monitoring of number of rescue analgesic consumed, duration of analgesia, numerical rating scale (NRS) at rest and on cough and any adverse effects.

Enrollment: 40 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

ASA I to III Elective surgery

Exclusion criteria

• Patient's refusal
• BMI > 35 kg/m2 or < 18 kg/m2
• Allergic or contraindication to drugs used in study
• Coagulopathy
• Local site infection
• Spine deformity
• Uncooperative or psychological illness
• Inability to comprehend pain scale
• Drugs not injected in target area

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 2 patient groups

Bupivacaine group

Active Comparator group

Description:

0.25% bupivacaine 20 ml in TAP block

Treatment:

Combination Product: bupivacaine and morphine

Bupivacaine morphine group

Experimental group

Description:

0.25% bupivacaine 20 ml with 3 mg morphine in TAP block

Treatment:

Combination Product: bupivacaine and morphine