Effects of Multimodal Analgesia on Serum MCP-1, BDNF, and MiRNA-124 in Hysterectomy Surgery

Udayana University

Status: Completed

Conditions: Inflammation; Chronic Pain; Inflammatory Response; Acute Pain

Treatments: Drug: Multimodal analgesia; Drug: Conventional intravenous analgesia

Study type: Interventional

Funder types: Other

Identifiers

NCT05069311

UNUD-CTR-FK240921-001

Details and patient eligibility

About

The inflammatory process is the main mechanism in the occurrence of acute postoperative pain. It is also the main risk for the development of acute pain into persistent pain. Inflammation occurs in the process of peripheral sensitization and central sensitization with various inflammatory mediators. Postoperatively, there will be proliferation and activation of microglia and astrocytes which will then activate inflammatory receptors and signaling cascades of neurotransmitters, cytokines, and chemokines. There has been a lot of clinical research evidence that multimodal analgesia can adequately treat acute pain and can prevent the development of acute postoperative pain into persistent pain and chronic postoperative pain, but the molecular mechanisms are not fully understood.

Enrollment: 62 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Scheduled for elective hysterectomy
• American Society of Anesthesiologists (ASA) physical status 1 to 3

Exclusion criteria

• allergy to studied drugs
• history of chronic pain
• history of hepatitis, depression, peptic ulcer, or acute myocardial infarction
• receive intraoperative massive blood transfusion
• prolonged coagulation
• body mass index >35 kg/m2
• patients with neurological deficits
• taking anti-platelet medications

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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62 participants in 1 patient group

Hysterectomy

Experimental group

Description:

Patients who undergo surgical hysterectomy that fits inclusion and exclusion criteria

Treatment:

Drug: Conventional intravenous analgesia

Drug: Multimodal analgesia