Effects of Music Beat on Motor Function in Individuals At Risk for Psychotic Onset and Schizophrenia Patients

Dr WANG Shumei

Status: Completed

Conditions: Psychosis; Schizophrenia; Parkinsonism; Dyskinesias

Treatments: Behavioral: Rhythmic auditory stimulation (RAS); Behavioral: no RAS

Study type: Interventional

Funder types: Other

Identifiers

NCT04929795

HSEARS20210610001

Details and patient eligibility

About

The purpose of this project is to investigate whether a 3-week training program involving music beat (serving as a type of rhythmic auditory stimulation) reduces the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients. It is hypothesized that the program is effective in reducing the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients.

Enrollment: 15 patients

Sex: All

Ages: 13 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

For at-risk participants:

Inclusion criteria:

1. A score of or above 9 in the Chinese version of the 16-item Prodromal Questionnaire (CPQ-16), or a score of or above 8.18 in the Chinese version of Community Assessment of Psychic Experiences with 15 items (CAPE-C15), or a score of or above 17 in Schizotypal Personality Questionnaire-Brief (SPQ-B);
2. an age of 13 years or above;
3. score > 60 in The Chinese version of Edinburgh Handedness Inventory (CH-EBI) to ensure right handedness; and
4. score ≥ 22 in Montreal Cognitive Assessment Hong Kong Version (HK-MoCA) to ensure no serious cognitive deficits so that they can understand instructions.

Exclusion criteria:

1. psychiatric diagnosis by self-report;
2. cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements;
3. taking psychiatric medications;
4. substance abuse; and
5. being pregnant.

For schizophrenia participants:

Inclusion criteria:

1. a diagnosis of schizophrenia without other psychiatric diseases;
2. the age ≥ 18 years;
3. score > 60 in CH-EBI to ensure right handedness; and
4. score ≥ 22 in HK-MoCA to ensure no serious cognitive deficits so that they can understand instructions.

Exclusion criteria:

1. cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements;
2. substance abuse; and
3. being pregnant.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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15 participants in 4 patient groups

at risk- RAS

Experimental group

Description:

At-risk individuals in the experimental group will undergo upper-limb movement training with the aid of music beat serving as a type of rhythmic auditory stimulation (RAS).

Treatment:

Behavioral: Rhythmic auditory stimulation (RAS)

at risk- no RAS

Active Comparator group

Description:

At-risk individuals in the control group will receive upper-limb training without the aid of RAS.

Treatment:

Behavioral: no RAS

schizophrenia- RAS

Experimental group

Description:

Schizophrenia patients in the experimental group will undergo upper-limb movement training with the aid of RAS.

Treatment:

Behavioral: Rhythmic auditory stimulation (RAS)

schizophrenia- no RAS

Active Comparator group

Description:

Schizophrenia patients in the control group will receive upper-limb training without the aid of RAS.

Treatment:

Behavioral: no RAS