Effects of Nicotinamide Riboside on Metabolism and Vascular Function

I

Iowa State University

Status

Completed

Conditions

Aging
Lipemia

Treatments

Dietary Supplement: Nicotinamide riboside chloride (Niagen)
Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT03501433
17-603

Details and patient eligibility

About

The purpose of this study is to determine the effects of Nicotinamide Riboside (NR) supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.

Full description

The purpose of this study is to determine the effects of 7 days of Nicotinamide Riboside (NR) or placebo supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.

Enrollment

16 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age 18 to 35 (young) and 60 to 75 (older)
  • Normo- or pre-hypertensive (blood pressure <140/90 mmHg)
  • Non-smokers
  • Able to give informed consent and participate in all laboratory visits

Exclusion criteria

  • Currently taking any medications that could interfere with cardiovascular or metabolic outcomes will be excluded from the study (e.g., beta-blockers)
  • Known metabolic (e.g. Type I or Type II diabetes, cardiovascular disease, etc.) or immunologic (e.g. HIV, cancer, autoimmune, etc.) diseases
  • Food allergies to egg, milk, soy or wheat
  • Women who are pregnant or planning to become pregnant during the course of the study,
  • Pacemaker or other implanted device
  • Unwilling to participate in the experimental protocol or blood draws will be excluded

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

16 participants in 2 patient groups, including a placebo group

Nicotinamide Riboside Chloride (Niagen)
Experimental group
Description:
7 days of nicotinamide riboside supplementation (250 mg/d x 2/day).
Treatment:
Dietary Supplement: Nicotinamide riboside chloride (Niagen)
Placebo
Placebo Comparator group
Description:
7 days of placebo supplementation (2/day)
Treatment:
Dietary Supplement: Placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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