Effects of Nicotinamide Riboside on Metabolism and Vascular Function

Iowa State University

Status

Completed

Conditions

Aging

Lipemia

Treatments

Dietary Supplement: Placebo

Dietary Supplement: Nicotinamide riboside chloride (Niagen)

Study type

Interventional

Funder types

Other

Identifiers

NCT03501433

17-603

Details and patient eligibility

About

The purpose of this study is to determine the effects of Nicotinamide Riboside (NR) supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.

Full description

The purpose of this study is to determine the effects of 7 days of Nicotinamide Riboside (NR) or placebo supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.

Enrollment

16 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 18 to 35 (young) and 60 to 75 (older)
Normo- or pre-hypertensive (blood pressure <140/90 mmHg)
Non-smokers
Able to give informed consent and participate in all laboratory visits

Exclusion criteria

Currently taking any medications that could interfere with cardiovascular or metabolic outcomes will be excluded from the study (e.g., beta-blockers)
Known metabolic (e.g. Type I or Type II diabetes, cardiovascular disease, etc.) or immunologic (e.g. HIV, cancer, autoimmune, etc.) diseases
Food allergies to egg, milk, soy or wheat
Women who are pregnant or planning to become pregnant during the course of the study,
Pacemaker or other implanted device
Unwilling to participate in the experimental protocol or blood draws will be excluded