Effects of Nicotine in Tobacco Smokers

University of Southern California

Status and phase: Completed; Phase 1

Conditions: Smoking (Tobacco) Addiction; Smoking, Tobacco

Treatments: Drug: Cigarette 1; Drug: Patch 1; Drug: Patch 2; Drug: Cigarette 2

Study type: Interventional

Funder types: Other

Identifiers

NCT03651869

28IR-0063

Details and patient eligibility

About

This study will examine mechanisms linking Obsessive-Compulsive Disorder symptomatology to tobacco dependence.

Enrollment: 221 patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• At least 21 years old
• Daily smoking at least 2 years

Exclusion criteria

• Currently pregnant or breastfeeding.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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221 participants in 4 patient groups

Condition 1

Experimental group

Treatment:

Drug: Cigarette 1

Drug: Patch 1

Condition 2

Experimental group

Treatment:

Drug: Cigarette 2

Drug: Patch 1

Condition 3

Experimental group

Treatment:

Drug: Patch 2

Drug: Cigarette 1

Condition 4

Experimental group

Treatment:

Drug: Patch 2

Drug: Cigarette 2