Effects of Nitrous Oxide: A Dose-Response Analysis - 5

The University of Chicago

Status: Completed

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: 30% N2O; Drug: 10% N2O; Drug: 20% N2O; Drug: 40% N2O

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000253

NIDA-08391-5

R01DA008391 (U.S. NIH Grant/Contract)

R01-08391-5

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the subjective, psychomotor, and reinforcing effects of nitrous oxide in healthy volunteers. This is a dose-response analysis.

Enrollment: 16 patients

Sex: All

Ages: 21 to 37 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

16 participants in 4 patient groups

Placebo + 10% N2O

Active Comparator group

Description:

0% N2O inhaled during psychomotor testing, 10% N2O inhaled during psycho motor testing, then subject's choice of the 2.

Treatment:

Drug: 10% N2O

Placebo + 20% N2O

Active Comparator group

Description:

Placebo inhaled during psychomotor testing, 20% N2O inhaled during psychomotor testing, then subject's choice of the 2.

Treatment:

Drug: 20% N2O

Placebo + 30% N2O

Active Comparator group

Description:

Placebo inhaled during psychomotor testing, 30% N2O inhaled during psychomotor testing, then subject's choice of the 2.

Treatment:

Drug: 30% N2O

Placebo + 40% N2O

Active Comparator group

Description:

Placebo inhaled during psychomotor testing, 40% N2O inhaled during psychomotor testing, then subject's choice of the 2.

Treatment:

Drug: 40% N2O