Effects of Non-calorie Sweeteners, Mono- and Disaccharides on Intestinal Barrier Function

University of Vienna

Status: Completed

Conditions: Dietary Habits; Endotoxemia

Treatments: Other: Dietary Intervention 3; Other: Dietary Intervention 2; Other: Dietary intervention 1; Other: Dietary Intervention 4

Study type: Interventional

Funder types: Other

Identifiers

NCT04788680

UVienna21

Details and patient eligibility

About

The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.

Full description

In the intervention study normal weight participants will receive beverages sweetened with non-nutritive sweeteners, mono- and disaccharides for a defined number of days. Before and after intervention parameters of intestinal barrier function will be assessed.

Enrollment: 18 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• No known history of metabolic diseases/disorders
• BMI <25 kg/m2

Exclusion criteria

• Food allergies or intolerances (esp. fructose intolerance and malabsorption)
• Chronic disease of the gastrointestinal tract
• Renal insufficiency
• Taking drugs affecting lipid or glucose metabolism

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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18 participants in 4 patient groups

Experimental: Beverage 1

Experimental group

Description:

Participants receive a beverage with a defined amount of non-nutritive sweetener.

Treatment:

Other: Dietary intervention 1

Experimental: Beverage 2

Experimental group

Description:

Participants receive a beverage with a defined amount of non-nutritive sweetener.

Treatment:

Other: Dietary Intervention 2

Experimental: Beverage 3

Experimental group

Description:

Participants receive a beverage with a defined amount of monosaccharide.

Treatment:

Other: Dietary Intervention 3

Experimental: Beverage 4

Experimental group

Description:

Participants receive a beverage with a defined amount of disaccharide.

Treatment:

Other: Dietary Intervention 4