Effects of Non-invasive Neuromodulation on Food Desire, Chewing Pattern, Executive Functions and Oxidative Stress.

Universidade Federal do Piauí

Status: Completed

Conditions: Inflammation; Mastication Disorder; Memory Disorders; Craving; Transcranial Direct Current Stimulation; Oxidative Stress; Executive Dysfunction

Treatments: Behavioral: speech therapy for chewing + real tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT05046145

tDCSONCRAVINGFOOD

Details and patient eligibility

About

From the change in self-regulation, memory is inhibited, allowing individuals to suppress or ignore unwanted or outdated associations and thus help to filter information relevant to dietary goals from irrelevant information. Provoking changes in neuroplasticity and cortical excitability contribute to the regulation of neural activity. Both could be modified by applying direct electrical current to the sensorimotor cortex, with polarity/current-dependent results, and their effect would last for hours after the end of stimulation. Transcranial Direct Current Stimulation (tDCS), translated into Portuguese as Estimulação Transcraniana por Corrente Contínua (ETCC) is a neuromodulating tool in which a low-intensity electrical current is applied to the scalp to modulate neuronal activity.

Enrollment: 36 patients

Sex: All

Ages: 18 to 59 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• being a health professional at the HU-UFPI (higher and technical levels);
• both sexes;
• Age between 20 and 59 years old.

Exclusion criteria

• Participants with communication disabilities (outbound or inbound);
• Type 1 and 2 diabetes
• low Body Mass Index (BMI; below 18.5),
• intracranial metal clip and/or prostheses;
• Abrupt change in weight (> 5 kg) in the last six months;
• the use will be excluded recreational use of psychoactive drugs,
• Being a smoker or using nicotine (tablet / absorbent),
• Having had significant recent trauma or traumatic brain injury,
• Present history of epilepsy,
• to be pregnant or under suspicion
• Missing teeth;
• Medical diagnosis of eating disorder or any psychiatric disorder,
• Having or having had cancer,
• Diagnosis of heart disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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36 participants in 2 patient groups

tDCS + speech therapy+ sham

Experimental group

Description:

Participants will receive real tDCS and tDCS sham for 5 sessions during each treatment period. The interstice period of the total intervention will be 25 days, with 15 days of wash out between the two interventions. The probabilistic, simple randomized sample will consist of participants with food cravings randomized into two groups, according to the presence or absence of changes in eating behavior and within each group there will be subdivision to receive or not neuromodulation, according to the flowchart

Treatment:

Behavioral: speech therapy for chewing + real tDCS

sham + tDCS + speech therapy

Experimental group

Description:

Participants will receive real tDCS and tDCS sham for 5 sessions during each treatment period. The interstice period of the total intervention will be 25 days, with 15 days of wash out between the two interventions. The probabilistic, simple randomized sample will consist of participants with food cravings randomized into two groups, according to the presence or absence of changes in eating behavior and within each group there will be subdivision to receive or not neuromodulation, according to the flowchart

Treatment:

Behavioral: speech therapy for chewing + real tDCS