Effects of Non-nutritive Sweeteners on the Composition of the Gut Microbiome

George Washington University (GW)

Status: Completed

Conditions: Diabetes; Obesity

Treatments: Other: carbonated water (control); Other: commercially-available diet soda

Study type: Interventional

Funder types: Other

Identifiers

NCT02877186

011512

Details and patient eligibility

About

This pilot study is being conducted to evaluate whether consumption of diet soda sweetened with sucralose and acesulfame-potassium leads to changes in the gut microbiota. Following a one week run-in period, healthy, young adults are randomized to consume either diet soda or carbonated water (control) three times per day for one week. Stool and urine samples are collected at baseline, following the run-in, and after the one-week intervention.

Enrollment: 22 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adults aged 18-35 years
• Consume less than 1 food/beverage with non-nutritive sweeteners per month
• Able and willing to consume diet soda three times daily for 1 week

Exclusion criteria

• Recent diet or significant weight change
• Antibiotic use in the past 3 months
• Diarrhea in the past two weeks
• Use of medications known to affect metabolism or weight
• Weight < 50 kg (110 lbs.)
• History of metabolic complications including high blood sugar, elevated cholesterol, or liver disease

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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22 participants in 2 patient groups, including a placebo group

Diet Soda

Experimental group

Description:

Consumption of diet soda three times daily for one week

Treatment:

Other: commercially-available diet soda

Carbonated Water

Placebo Comparator group

Description:

Consumption of plain, unsweetened, carbonated water three times daily for one week

Treatment:

Other: carbonated water (control)