Effects of Nutritional Supplementation of Leucine and Polyunsaturated Fatty Acids on Muscle Health in the Elderly

Chang Gung Medical Foundation

Status: Enrolling

Conditions: Sarcopenia in Elderly; Sarcopenia

Treatments: Dietary Supplement: Animal-Based Oil Group; Dietary Supplement: Plant-Based Oil Group

Study type: Interventional

Funder types: Other

Identifiers

NCT06991855

202500394A3

Details and patient eligibility

About

Population aging has become a significant global concern, and Taiwan is set to officially enter the "super-aged society" in 2025. As individuals age, various physiological functions gradually decline, including a reduction in muscle mass, which is a key aspect of the aging process.

This interventional study aims to investigate the effects of leucine-rich protein combined with polyunsaturated fatty acid supplementation on middle-aged and elderly individuals (aged 50 and above) who are at high risk for sarcopenia.

Enrollment: 90 estimated patients

Sex: All

Ages: 50 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 50 years
• ASMI < 7 kg/m2 in men
• ASMI < 5.7 kg/m2 in women
• Grip strength < 28 kg in men
• Grip strength < 18 kg in women
• Walk speed < 1 m/s

Exclusion criteria

• People who are allergic to supplements
• cancer
• heart failure
• kidney disease
• autoimmune disease
• neurodegenerative disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 2 patient groups

Animal-Based Oil Group

Experimental group

Description:

Participants in this group will supplement with animal-based poly-unsaturated oil. The supplementation will be maintained for 12 weeks.

Treatment:

Dietary Supplement: Animal-Based Oil Group

Plant-Based Oil Group

Experimental group

Description:

Participants in this group will supplement with plant-based poly-unsaturated oil. The supplementation will be maintained for 12 weeks.

Treatment:

Dietary Supplement: Plant-Based Oil Group