Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic (H2PAP)

University Hospital, Strasbourg, France

Status: Completed

Conditions: Hypoxia and Hypercapnia; Hypercapnia; Pulmonary Vascular Sensibility in Hypoxia

Treatments: Device: Hypoxia and hypercapnia (Altitrainer NP 190); Device: Hypercapnia inhalation (Altitrainer NP 190); Device: Hypoxia inhalation (Altitrainer NP 190)

Study type: Observational

Funder types: Other

Identifiers

NCT01898858

5546

Details and patient eligibility

About

The aim of this study is to describe the pulmonary hemodynamic evolution at rest and during a short constant load exercise in 4 conditions :

• normoxia
• hypoxia
• hypercapnia
• association hypoxia and hypercapnia

Enrollment: 8 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy male
• exercise capacity between 100 and 130 % of theorical values

Exclusion criteria

• smoker
• headache
• impossibility to perform an exercise test
• no tricuspid regurgitation on the echocardiography

Trial design

8 participants in 3 patient groups

HYPOXIA

Treatment:

Device: Hypoxia inhalation (Altitrainer NP 190)

HYPERCAPNIA

Treatment:

Device: Hypercapnia inhalation (Altitrainer NP 190)

HYPOXIA + HYPERCAPNIA

Treatment:

Device: Hypoxia and hypercapnia (Altitrainer NP 190)