Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function

The University of Hong Kong (HKU)

Status: Completed

Conditions: Smoking; Obstructive Sleep Apnea

Study type: Observational

Funder types: Other

Identifiers

NCT00957463

UW 08-023

Details and patient eligibility

About

The hypothesis of this study is that either obstructive sleep apnea (OSA) or cigarette smoking (CS) exposure would produce oxidative stress and inflammation leading to endothelial injury, and the combined exposure would be additive or synergistic.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• No acute illness
• No hospitalization in past 4 weeks
• Absence of medical comorbidity such as hypertension, ischemic heart disease, diabetes and hyperlipidemia, renal impairment, vasculitis or Raynaud's syndrome, peripheral vascular disease especially Buerger's disease, aortic disease (aortic aneurysm or dilatation), cancer, thrombocytopenia, coagulation disorder or other chronic medical illness

Exclusion criteria

• Mentally incapacitated

Trial design

150 participants in 4 patient groups

smoker, with high apnea-hypopnea index

Description:

subjects who smoke either in the past or currently, with confirmed moderate-severe OSA

smoker, mild OSA or without OSA

Description:

subjects who smoke either in the past or currently, with mild OSA or without OSA

nonsmoker, with high apnea-hypopnea index

Description:

subjects who never smoke, with confirmed moderate-severe OSA

nonsmoker, with mild OSA or without OSA

Description:

subjects who never smoke, with mild OSA or without OSA