Effects of Omega-3 Fatty Acids and Menaquinone-7 on Thrombotic Tendency

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Atherosclerosis

Treatments: Dietary Supplement: krill oil; Dietary Supplement: menaquinone-7; Dietary Supplement: fish oil

Study type: Interventional

Funder types: Other

Identifiers

NCT00732576

MEC 07-3-067

Details and patient eligibility

About

Omega-3 fatty acids are notably present in fish oil and krill oil, and are known to have beneficial effects on the vasculature. Vitamin K2 is known for preventing vascular calcification. In this study we investigate a potential synergy between the effects of either fish or krill oil and menaquinone-7, which is one of K2 vitamins.

Enrollment: 57 patients

Sex: All

Ages: 25 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects - BMI < 30
• written informed consent

Exclusion criteria

• Use of oral anticoagulants
• Coagulation disorders
• Use of multivitamin supplements
• Use of corticosteroids, anticonceptives
• hypertriglyceridemia, hypercholesterolemia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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57 participants in 8 patient groups

1

Active Comparator group

Description:

9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA)

Treatment:

Dietary Supplement: fish oil

2

Active Comparator group

Description:

9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (10 µg)

Treatment:

Dietary Supplement: fish oil

Dietary Supplement: menaquinone-7

3

Active Comparator group

Description:

9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 2 capsules of menaquinone-7 per day (20 µg per day)

Treatment:

Dietary Supplement: fish oil

Dietary Supplement: menaquinone-7

4

Active Comparator group

Description:

9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (45 µg per day)

Treatment:

Dietary Supplement: fish oil

Dietary Supplement: menaquinone-7

5

Active Comparator group

Description:

9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA)

Treatment:

Dietary Supplement: krill oil

6

Active Comparator group

Description:

9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (10 µg)

Treatment:

Dietary Supplement: krill oil

Dietary Supplement: menaquinone-7

7

Active Comparator group

Description:

9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 2 capsules of menaquinone-7 per day (20 µg per day)

Treatment:

Dietary Supplement: krill oil

Dietary Supplement: menaquinone-7

8

Active Comparator group

Description:

9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (45 µg per day)

Treatment:

Dietary Supplement: krill oil

Dietary Supplement: menaquinone-7