Effects of Onion Peel Extract on Endothelial Function

Kyung Hee University

Status and phase: Completed; Phase 4

Conditions: Obese; Overweight; Healthy

Treatments: Drug: Placebo; Drug: Onion peel extract

Study type: Interventional

Funder types: Other

Identifiers

NCT02180022

Onion-EPC

Seoul, Korea (Other Grant/Funding Number)

Details and patient eligibility

About

Acute or chronic intake of polyphenol-rich foods has been reported to improve endothelial function. Quercetin, found abundantly in onion, is a potent antioxidant flavonoid. This study was designed to investigate whether consumption of onion peel extract (OPE) improves endothelial function in healthy overweight and obese subjects.

Full description

Epidemiological studies have shown a rapid increase in the prevalence of overweight and obesity, not only in adults but also in children and adolescents, thus increasing the risk of early development of cardiovascular disease (CVD). Quercetin, found abundantly in onion, prevents the induction of endothelial dysfunction, superoxide production, and overexpression by angiotensin II in the rat aorta. Furthermore, in our previous study we showed that supplementation with quercetin-rich onion peel extract (OPE) influenced adipokine expression, thus addressing its modulatory effect on obesity-induced inflammation, and improved insulin resistance by alleviating the metabolic dysregulation of free fatty acids, suppressing oxidative stress, upregulating glucose uptake, and downregulating inflammatory gene expression. But there are limited studies on the relationship between quercetin supplementation and endothelial dysfunction in humans.

Enrollment: 62 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 20 to 60 years
• BMI >23 kg/m2
• abdominal circumference > 90 cm in males or >85 cm in females

Exclusion criteria

• hypertension (>140/90 mmHg),
• diabetes
• any cardiovascular disease,
• kidney disease,
• thyroid disease
• cerebrovascular disease
• liver disease (bilirubin level >2 mg/dl)
• pregnancy

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

62 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Patients treated with placebo for 12 weeks

Treatment:

Drug: Placebo

Onion peel extract

Experimental group

Description:

Patients treated with onion peel extract for 14 days

Treatment:

Drug: Onion peel extract