Effects of Oral Cancer Treatments on Upper Esophageal Opening During Swallowing

University of Wisconsin (UW)

Status: Terminated

Conditions: Cancer of Head and Neck

Treatments: Diagnostic Test: Videofluoroscopic imaging (VFSS) with high-resolution manometry (HRM)

Study type: Observational

Funder types: Other

Identifiers

NCT04658342

2020-0495 (Other Identifier)

Protocol Version 4/26/2022 (Other Identifier)

UW20051 (Other Identifier)

A539770 (Other Identifier)

SMPH/SURGERY/OTOLARYNGOLOGY (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to investigate post-operative and post-radiation upper esophageal sphincter opening measures in oral cancer patients, compare measures to age- and gender-matched healthy adults, and determine relationships with patient swallowing outcomes and quality of life.

Enrollment: 5 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Oral cancer that includes tongue or floor of mouth clinical stage T1 or higher
• May have disease that extends to base of tongue or other site as long as floor of mouth or tongue are involved
• Adults at least 18 years of age

Exclusion criteria

• Oral cancer of the lip, cheek, palate or other site not impacting tongue or floor of mouth musculature
• History of floor of mouth, tongue base, pharyngeal or laryngeal surgical resection
• History of radiation treatment to the head and neck
• History of dysphagia prior to onset of oral cancer symptoms
• Allergy to lidocaine, barium, adhesive tape or apple flavoring
• Woman of childbearing years who are pregnant

Trial design

5 participants in 1 patient group

Oral Cancer Patients

Treatment:

Diagnostic Test: Videofluoroscopic imaging (VFSS) with high-resolution manometry (HRM)